Daily Brief

Leash Biosciences built a platform to physically measure thousands of proteins against millions of molecules. In this followup to our Leash Bio podcast with cofounder Ian Quigley, he returns to discuss the release of Minos, Leash’s framework of pre-measured experimental worlds that scientific agents can explore. Ian goes into how scientific agents traverse these environments, whether they use information from prior experiments to inform future choices, how good they get at medicinal chemistry, and how their broad decision making abilities affect their performance. We cover: - Huge action s

An agent’s sandbox can die without taking the whole agent with it. That’s the idea behind “the brain and the hands,” Anthropic’s architecture for Claude Managed Agents. Now that the dust has settled on Opus 5.5, it is universally agreed to be the best model in the world. In this conversation with Katelyn Lesse and Angela Jiang, Anthropic’s Heads of Engineering and of Product, goes inside the systems that turn model capabilities into products developers can use. We cover: - Why Anthropic separated the agent harness, session state and execution environment. - Letting agents use credentials wi